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Gut Microbiota Dysbiosis Drives the Development of Colorectal Cancer
- Source :
- Digestion. 102(4)
- Publication Year :
- 2020
-
Abstract
- Background: The gut microbiota is a diverse community of microbes that maintain the stability of the intestinal environment. Dysbiosis of the gut microbiota has been linked to gastrointestinal diseases, such as colorectal cancer (CRC) – a leading cause of death for cancer patients. Summary: Candidate pathogens have been identified using bacterial culture and high-throughput sequencing techniques. Currently, there is evidence to show that specific intestinal microbes drive CRC development and progression, yet their pathogenic mechanisms are still unclear. Key Messages: In this review, we describe the known healthy gut microbiota and its changes in CRC. We especially focus on exploring the pathogenic mechanisms of gut microbiota dysbiosis in CRC. This is crucial for explaining how gut microbiota dysbiosis drives the process of colorectal carcinogenesis and tumor progression. Evaluation of changes in the gut microbiota during CRC development and progression offers a new strategy for the diagnosis and treatment of this disease.
- Subjects :
- Colorectal cancer
Carcinogenesis
Disease
Gut flora
medicine.disease_cause
digestive system
03 medical and health sciences
0302 clinical medicine
medicine
Humans
biology
Gastroenterology
Cancer
Pathogenic bacteria
biology.organism_classification
medicine.disease
Gastrointestinal Microbiome
Intestines
Tumor progression
030220 oncology & carcinogenesis
Immunology
Dysbiosis
030211 gastroenterology & hepatology
Colorectal Neoplasms
Subjects
Details
- ISSN :
- 14219867
- Volume :
- 102
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Digestion
- Accession number :
- edsair.doi.dedup.....6626a8548309cc79f75ac8839bc4a80b