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Use of Vascular Endothelial Growth Factor-D As a Targeted Therapy in Lymphedema Treatment: A Comprehensive Literature Review
- Source :
- Lymphatic Research and Biology. 20:3-6
- Publication Year :
- 2022
- Publisher :
- Mary Ann Liebert Inc, 2022.
-
Abstract
- Background: Lymphangiogenic growth factors, such as vascular endothelial growth factor (VEGF)-D, are subjects of interest in studies of targeted therapies in lymphedema treatment. Methods and Results: We conducted a systematic review assessing the use of VEGF-D as a targeted therapy in lymphedema treatment. We hypothesized that VEGF-D was a promising therapy to induce lymphangiogenesis. Our search yielded 90 studies in the literature, but only 4 articles fulfilled our study eligibility criteria, and they were all experimental studies using viral gene transfer. The majority of the studies were conducted on small animals (mice) and investigated the effects of VEGF-D on lymph node transfer. All authors agreed about VEGF-D's lymphangiogenic potential, but they noticed that VEGF-C induced a superior lymphangiogenesis, and one study noticed that VEGF-D induced seroma. Conclusions: The publications assessing the use of VEGF-D as a targeted therapy in lymphedema treatment were able to demonstrate its lymphangiogenic potential. Nonetheless, further studies are still necessary to investigate VEGF-D's efficacy and safety in lymphedema treatment on patients.
- Subjects :
- Vascular Endothelial Growth Factor A
Oncology
medicine.medical_specialty
medicine.medical_treatment
Vascular Endothelial Growth Factor D
Targeted therapy
Mice
chemistry.chemical_compound
Study Eligibility Criteria
Internal medicine
medicine
Animals
Humans
Lymphedema
Lymphangiogenesis
Lymph node
business.industry
medicine.disease
Vascular endothelial growth factor
medicine.anatomical_structure
chemistry
Seroma
Lymph Nodes
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15578585 and 15396851
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Lymphatic Research and Biology
- Accession number :
- edsair.doi.dedup.....66218f53b43589952128c59447e0b895