Back to Search
Start Over
Impact of a Modified HistoGel Method for Processing Endocervical Curettage Specimens on Diagnostic Yield
- Source :
- American Journal of Clinical Pathology. 155:141-147
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Objectives Endocervical curettage (ECC) specimens may be limited by scant tissue. We evaluated whether a cellular concentration processing method could improve their diagnostic quality. Methods Between October 2018 and June 2019, ECC specimens were assigned chronologically to one of two groups: nonconcentrated ECC (NECC) or concentrated ECC (CECC). NECC specimens underwent routine histologic processing. CECC specimens were processed using a published HistoGel-based cell block method. We reviewed diagnoses for ECCs, concurrent cervical biopsies and/or loop electrosurgical excision procedures (LEEPs), and preceding Papanicolaou (Pap) smears. We performed multivariate logistic regression analyses to evaluate the impact of processing method on ECC adequacy and discordance between Pap smear and worst tissue diagnoses. Results NECC and CECC adequacy was 88.2% and 84.7% (P = .06). ECC adequacy was greater if concurrent biopsy/LEEP was performed (odds ratio [OR] = 1.76, P < .01). Discordance between Pap smear and worst tissue diagnoses was 9.5% and 13.3% (P = .04) for cases with NECC and CECC processing, although processing method was not significant in multivariate analysis (OR = 0.74, P = .11). Adequate ECC sampling and concurrent biopsy/LEEP were independently associated with concordance between Pap smear and worst tissue diagnosis (OR = 0.46, P < .01 and OR = 0.65, P = .02). Conclusions ECC processing method did not significantly affect either specimen adequacy (P = .06) or diagnostic discordance (P = .11) when controlled for other factors.
- Subjects :
- Adult
medicine.medical_specialty
Multivariate analysis
Concordance
Uterine Cervical Neoplasms
Papanicolaou stain
Cervix Uteri
Endocervical curettage
Curettage
03 medical and health sciences
0302 clinical medicine
Biopsy
medicine
Humans
Sampling (medicine)
Cell block
Vaginal Smears
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
business.industry
General Medicine
Odds ratio
Middle Aged
Uterine Cervical Dysplasia
030220 oncology & carcinogenesis
Female
Radiology
business
Subjects
Details
- ISSN :
- 19437722 and 00029173
- Volume :
- 155
- Database :
- OpenAIRE
- Journal :
- American Journal of Clinical Pathology
- Accession number :
- edsair.doi.dedup.....6613e267ff68657d40d79ea6cd5ea09f