Renal Function in Renal Adenocarcinoma

Renal function tests with special reference to the renal haemodynamics have been carried out on 11 cases of renal carcinoma. Selective clearance of inulin and PAH and the extraction ratio for PAH and oxygen were determined.The kidneys with tumours showed lower urine flow, CIN, EPAH and oxygen A-V difference than the control organs. TRBF, on the other hand, was higher for the tumour group.The reduction in EPAH suggests that there was shunting of blood past active tubular epithelium; the reduction in the oxygen A-V difference shows an A-V shunting that is a blood flow via parenchyma with a lowered oxygen extraction. It would seem that the shunting increased with the malignancy of the tumour.