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Mortality and Heart Rate in the Elderly: Role of Cognitive Impairment
- Source :
- Experimental Aging Research. 33:127-144
- Publication Year :
- 2007
- Publisher :
- Informa UK Limited, 2007.
-
Abstract
- Mortality related to heart rate (HR) increase in the elderly has not yet been well established. To ascertain the relationships among cognitive impairment (CI), mortality, and HR increase, the authors prospectively studied a random sample of elderly subjects stratified according to presence or absence of CI. Elderly subjects randomly selected in 1991 (n = 1332) were followed up for 12 years. Mortality was established in 98.1% of the subjects. When HR was stratified in quartiles (69, 70-75, 76-80, and80 bpm), mortality was linearly associated with increased HR in all (from 47.7 to 57.0; r2 = .43, p = .019) and in subjects without (from 41.7 to 51.1%; r2 = .50, p = .043) but not in those with CI (from 57.5 to 66.1; r2 = .20, p = .363). Cox regression analysis, adjusted for several variables, shows that HR doesn't predict mortality in all subjects (RR 0.69; 95% CI = 0.27-1.73) or in those with CI (RR 0.91; 95% CI = 0.81-1.02). In contrast, HR predicts mortality in subjects without CI (RR 1.10; 95% CI = 1.00-1.22). Hence, HR increase is a predictor of mortality in elderly subjects without CI. However, when considering all elderly subjects and those with CI, HR increase seems to have no effect on mortality. Thus, CI should be considered when focusing on HR increase as risk factor for mortality in the elderly.
- Subjects :
- Male
Aging
medicine.medical_specialty
Settore MED/09
Age Distribution
Arts and Humanities (miscellaneous)
Heart Rate
Cause of Death
Internal medicine
Heart rate
medicine
Humans
Cognitive impairment
Life Style
General Psychology
Aged
Aged, 80 and over
Proportional hazards model
Arrhythmias, Cardiac
Surgery
Quartile
Regression Analysis
Female
Geriatrics and Gerontology
Cognition Disorders
Psychology
Subjects
Details
- ISSN :
- 10964657 and 0361073X
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Experimental Aging Research
- Accession number :
- edsair.doi.dedup.....660541a49707b0b6874c3cfabbb345b1