Activation of resident brain microglia by viral infection leads to transient clearance of infectious prions from the brain

Authors :: Krasemann, S
Schröck, K
Fanek, Z
Butovsky, O
Glatzel, M
Source :: 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN); 20150826-20150828; Berlin; DOC15dgnnND6 /20150825/
Publication Year :: 2015
Publisher :: German Medical Science GMS Publishing House, 2015.
Abstract: Introduction: Prion diseases are transmissible, fatal disorders, where the conversion of the cellular prion protein (PrPC) into a misfolded variant (PrPSc) leads to neurodegeneration. The spreading of the misfolded isoform to and within the brain is an essential step in the establishment and spreading[for full text, please go to the a.m. URL]<br />60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN)

Subjects :: ddc: 610
animal diseases
610 Medical sciences
Medicine
nervous system diseases

Language :: English
Database :: OpenAIRE
Journal :: 60th Annual Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN); 20150826-20150828; Berlin; DOC15dgnnND6 /20150825/
Accession number :: edsair.doi.dedup.....6601c04ad27aade925a1c1025323dc74
Full Text :: https://doi.org/10.3205/15dgnn06

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