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Second nationwide surveillance of bacterial pathogens in patients with acute uncomplicated cystitis conducted by Japanese Surveillance Committee from 2015 to 2016: antimicrobial susceptibility of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus saprophyticus
- Source :
- Journal of Infection and Chemotherapy. 25:413-422
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- The Japanese Surveillance Committee conducted a second nationwide surveillance of antimicrobial susceptibility patterns of uropathogens responsible for acute uncomplicated cystitis (AUC) in premenopausal patients aged 16–40 years old at 31 hospitals throughout Japan from March 2015 to February 2016. In this study, the susceptibility of causative bacteria (Escherichia coli, Klebsiella pneumoniae, Staphylococcus saprophyticus) for various antimicrobial agents was investigated by isolation and culturing of organisms obtained from urine samples. In total, 324 strains were isolated from 361 patients, including E. coli (n = 220, 67.9%), S. saprophyticus (n = 36, 11.1%), and K. pneumoniae (n = 7, 2.2%). The minimum inhibitory concentrations (MICs) of 20 antibacterial agents for these strains were determined according to the Clinical and Laboratory Standards Institute (CLSI) manual. At least 93% of the E. coli isolates showed susceptibility to fluoroquinolones and cephalosporins, whereas 100% of the S. saprophyticus isolates showed susceptibility to fluoroquinolones and aminoglycosides. The proportions of fluoroquinolone-resistant and extended-spectrum β-lactamase (ESBL)-producing E. coli strains were 6.4% (13/220) and 4.1% (9/220), respectively. The antimicrobial susceptibility of K. pneumoniae was retained during the surveillance period, while no multidrug-resistant strains were identified. In summary, antimicrobial susceptibility results of our second nationwide surveillance did not differ significantly from those of the first surveillance. Especially the numbers of fluoroquinolone-resistant and ESBL-producing E. coli strains were not increased in premenopausal patients with AUC in Japan.
- Subjects :
- Adult
Male
0301 basic medicine
Microbiology (medical)
Adolescent
Klebsiella pneumoniae
medicine.drug_class
Resistance
030106 microbiology
Cephalosporin
Antimicrobial susceptibility
Microbial Sensitivity Tests
Urine
medicine.disease_cause
beta-Lactamases
Microbiology
Young Adult
03 medical and health sciences
0302 clinical medicine
Japan
Drug Resistance, Multiple, Bacterial
Cystitis
Escherichia coli
Humans
Medicine
Pharmacology (medical)
030212 general & internal medicine
Acute uncomplicated cystitis
Staphylococcus saprophyticus
Surveillance
biology
business.industry
Middle Aged
Antimicrobial
biology.organism_classification
Anti-Bacterial Agents
Infectious Diseases
Susceptibility
Epidemiological Monitoring
Female
business
Bacteria
Subjects
Details
- ISSN :
- 1341321X
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Journal of Infection and Chemotherapy
- Accession number :
- edsair.doi.dedup.....65ff8c9fa58b1aa0d2bd80772256cd09