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Effects of mild induced hypothermia during experimental sepsis*
- Source :
- Critical Care Medicine, Critical Care Medicine, Lippincott, Williams & Wilkins, 2006, 34 (10), pp.2621-3. ⟨10.1097/01.CCM.0000240231.76837.DC⟩
- Publication Year :
- 2006
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2006.
-
Abstract
- International audience; OBJECTIVES: The potential advantages of lowering core temperature during sepsis are to lower energy requirement and to activate various cell-protecting pathways. We experimentally investigated whether postconditioning temperature modifications influence survival duration during experimental sepsis. DESIGN: A prospective, randomized, experimental animal study. SETTING: University laboratory. SUBJECTS: Eighteen male Sprague-Dawley rats (median 326 g, range 310-347 g). INTERVENTIONS: After anesthesia, experimental sepsis was induced by cecal ligation and perforation. The animals were subsequently assigned a core temperature range: normothermia (37 degrees C), hyperthermia (42 degrees C), and mild hypothermia (32 degrees C). Anesthesia and analgesia were continuously maintained until death. MEASUREMENTS AND MAIN RESULTS: Plasma lactate and pyruvate concentrations were measured at sepsis induction (H0), 4 hrs later (H4), and/or at the time of death. A significant increase in lactate concentration was observed at the time of death in the 42 degrees C group (p = .04). Lactate-to-pyruvate ratio increased in the 32 degrees C (at H4) and 42 degrees C (at the time of death) groups (p = .04). A linear correlation between a longer survival duration and a lower assigned core temperature was observed (from 61 +/- 10 mins at 42 degrees C to 289 +/- 17 mins at 37 degrees C and to 533 +/- 69 mins at 32 degrees C; R = .959, p < .0001). CONCLUSIONS: The current results demonstrate that postconditioning hypothermia was associated with increased survival duration during experimental sepsis. Whether the observed benefits on survival duration are due to potential impacts on energy metabolism or to an anti-inflammatory effect of hypothermia requires further investigation.
- Subjects :
- Male
Resuscitation
MESH: Rats
MESH: Random Allocation
Sepsis syndrome
MESH: Rats, Sprague-Dawley
030204 cardiovascular system & hematology
Core temperature
Critical Care and Intensive Care Medicine
Lower energy
Rats, Sprague-Dawley
Sepsis
Random Allocation
03 medical and health sciences
0302 clinical medicine
Hypothermia, Induced
Intensive care
[SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]
medicine
Animals
MESH: Animals
MESH: Sepsis
MESH: Hypothermia, Induced
business.industry
030208 emergency & critical care medicine
Hypothermia
medicine.disease
Survival Analysis
MESH: Male
Rats
3. Good health
Sprague dawley
MESH: Survival Analysis
Anesthesia
medicine.symptom
business
Subjects
Details
- ISSN :
- 00903493
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Critical Care Medicine
- Accession number :
- edsair.doi.dedup.....65fe17a97813ec0bdd6ed3247679355d