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Serum concentrations of cytokines and lung cancer survival in African Americans and Caucasians
- Source :
- Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 18(1)
- Publication Year :
- 2009
-
Abstract
- Accumulating evidence suggests a role for inflammation in the development and progression of cancer. Our group recently identified a cytokine gene signature in lung tissue associated with lung cancer prognosis. Therefore, we hypothesized that concentrations of circulating cytokines in serum may be associated with lung cancer survival. Ten serum cytokines, namely, interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, granulocyte macrophage colony-stimulating factor, interferon (IFN)-γ, and tumor necrosis factor-α, were assessed in 353 non–small cell lung cancer cases from a case-control study of lung cancer in the greater Baltimore, Maryland area. Cytokines were measured using an ultrasensitive electrochemiluminescence immunoassay. IL-6 serum concentrations (≥4.0 pg/mL) were associated with significantly poorer survival in both African Americans [hazard ratio (HR), 2.71; 95% confidence interval (CI), 1.26-5.80] and Caucasians (HR, 1.71; 95% CI, 1.22-2.40). IL-10 (HR, 2.62; 95% CI, 1.33-5.15) and IL-12 (HR, 1.98; 95% CI, 1.14-3.44) were associated with lung cancer survival only in African Americans. Some evidence for an association of tumor necrosis factor-α levels with survival in Caucasians was observed, although these results were not significant. These hypothesis-generating findings indicate that selected serum cytokine concentrations are associated with lung cancer survival, and indicate that further research is warranted to better understand the mechanistic underpinnings of these associations. (Cancer Epidemiol Biomarkers Prev 2009;18(1):215–22)
- Subjects :
- Oncology
Male
medicine.medical_specialty
Lung Neoplasms
Epidemiology
medicine.medical_treatment
White People
Article
Internal medicine
Carcinoma, Non-Small-Cell Lung
medicine
Humans
Prospective Studies
Lung cancer
Prospective cohort study
Survival analysis
Aged
Maryland
business.industry
Respiratory disease
Hazard ratio
Cancer
medicine.disease
Survival Analysis
Black or African American
Cytokine
Case-Control Studies
Immunology
Cytokines
Tumor necrosis factor alpha
Female
business
Subjects
Details
- ISSN :
- 10559965
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Accession number :
- edsair.doi.dedup.....65fdbcf98a8467d6bb9ec668f0319f74