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Increased Transfusion Requirements with Pharmacologic Thromboembolism Prophylaxis During Inflammatory Bowel Disease Exacerbation
- Source :
- Digestive diseases and sciences. 64(11)
- Publication Year :
- 2018
-
Abstract
- Inflammatory bowel disease (IBD) exacerbation requiring hospitalization increases the risk of venous thromboembolism (VTE), and current guidelines recommend pharmacologic VTE prophylaxis (PVTEP). Bleeding risks with PVTEP in this population are poorly defined, and no study has investigated packed red blood cell (PRBC) transfusion requirements in this population. We conducted a chart review of all adult hospitalizations for IBD exacerbation within the Northwell Healthcare system. Patient characteristics recorded included demographics, disease type ulcerative colitis or Crohn’s disease, severe disease defined by inpatient corticosteroid or biologic use, and admission hemoglobin. Inpatient use of PVTEP and anti-platelet therapies were identified. The primary outcome was the occurrence of any packed red blood cell (PRBC) transfusion. In total, 717 patients met inclusion criteria, accounting for 891 admissions. PVTEP was used during 60.4% of admissions, and 11.1% of patient admissions included a transfusion event. Severe disease patients receiving PVTEP had an 18.6% transfusion risk, versus 11.1% for those not receiving PVTEP, OR 1.82, CI (1.04–3.17). One multivariable analysis transfusion was associated with PVTEP, OR 2.11, 95% CI 1.18, 3.77, p = 0.0120, disease severity OR 3.17, 95% CI 1.81,5.54, p
- Subjects :
- Adult
Male
medicine.medical_specialty
Exacerbation
Physiology
medicine.medical_treatment
Population
Inflammatory bowel disease
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Blood Transfusion
education
Contraindication
Aged
Retrospective Studies
education.field_of_study
Crohn's disease
business.industry
Gastroenterology
Thromboembolism Prophylaxis
Bowel resection
Venous Thromboembolism
Middle Aged
medicine.disease
Inflammatory Bowel Diseases
Ulcerative colitis
030220 oncology & carcinogenesis
Disease Progression
030211 gastroenterology & hepatology
Female
business
Post-Exposure Prophylaxis
Subjects
Details
- ISSN :
- 15732568
- Volume :
- 64
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Digestive diseases and sciences
- Accession number :
- edsair.doi.dedup.....65fba2389bad9a1af160df869e06f8ec