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Cerebrospinal fluid and serum neuron-specific enolase in acute benign headache
- Source :
- Cephalalgia : an international journal of headache. 28(5)
- Publication Year :
- 2008
-
Abstract
- We determined the cerebrospinal fluid (CSF) and serum neuron-specific enolase (NSE) concentrations in 19 patients with acute benign headache. All patients had normal neurological examination, CSF and head computed tomography scan. The final diagnoses were: primary thunderclap headache ( n = 7), primary exertional headache ( n = 3), primary cough headache ( n = 1), migraine without aura ( n = 4), headache unspecified ( n = 2), probable infrequent episodic tension-type headache ( n = 1), headache attributed to hypertensive crisis without hypertensive encephalopathy ( n = 1). A group of 108 healthy subjects served as controls. CSF NSE concentration was 14.16 ng/ml [95% confidence interval (CI) 11.86, 16.47)] in the headache sample (controls 17.19 ng/ml, 95% CI 16.23, 18.15). Serum NSE concentration was 7.50 ng/ml (95% CI 5.20, 9.80) in the headache sample (controls 8.45 ng/ml, 95% CI 7.67, 9.23). CSF/serum ratio was 2.81 (95% CI 2.21, 3.40) in the headache sample (controls 2.23, 95% CI 2.03, 2.42). Acute benign headache is not associated with neuronal damage as estimated by means of CSF and serum NSE concentration.
- Subjects :
- Adult
Male
Hypertensive encephalopathy
Aura
Enolase
Primary Exertional Headache
Neurological examination
Sensitivity and Specificity
Cerebrospinal fluid
Medicine
Humans
Aged
Aged, 80 and over
medicine.diagnostic_test
business.industry
Headache
General Medicine
Middle Aged
medicine.disease
Migraine
Anesthesia
Phosphopyruvate Hydratase
Acute Disease
Primary Cough Headache
Female
Neurology (clinical)
business
Biomarkers
Subjects
Details
- ISSN :
- 14682982
- Volume :
- 28
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Cephalalgia : an international journal of headache
- Accession number :
- edsair.doi.dedup.....65fa05bf89aa8815777a0f7982934397