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Recurrent Kikuchi-Fujimoto Disease Successfully Treated by the Concomitant Use of Hydroxychloroquine and Corticosteroids
- Source :
- Internal Medicine
- Publication Year :
- 2017
- Publisher :
- Japanese Society of Internal Medicine, 2017.
-
Abstract
- Kikuchi-Fujimoto disease (KFD) is a benign disease of unknown etiology characterized by lymphadenopathy and a fever. For the majority of patients with KFD, the course is self-limited; however, the optimum method of managing recurrent cases has not yet been established. We herein report a case of a 42-year-old Japanese woman with KFD (confirmed by a lymph node biopsy). Although high-dose prednisolone (PSL) rapidly induced remission, she experienced four recurrences on treatment tapering. Concomitant use of hydroxychloroquine (HCQ) with low-dose PSL induced continuous remission. This is the first case to suggest the effectiveness of HCQ for recurrent KFD in a Japanese patient.
- Subjects :
- Adult
Kikuchi-Fujimoto disease
medicine.medical_specialty
hydroxychloroquine
Prednisolone
Lymph node biopsy
Case Report
Disease
03 medical and health sciences
0302 clinical medicine
Recurrence
Internal Medicine
medicine
Humans
030212 general & internal medicine
030203 arthritis & rheumatology
Kikuchi-Fujimoto Disease
Dose-Response Relationship, Drug
Benign disease
medicine.diagnostic_test
business.industry
histiocytic necrotizing lymphadenitis
Hydroxychloroquine
General Medicine
Dermatology
Surgery
Concomitant
Etiology
Drug Therapy, Combination
Female
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 13497235 and 09182918
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Internal Medicine
- Accession number :
- edsair.doi.dedup.....65e71522bf2e999209cd6ab4288ba434