Back to Search
Start Over
ERK1 and ERK2 activation modulates diet-induced obesity in mice
- Source :
- Biochimie, Biochimie, Elsevier, 2017, 137, pp.78-87. 〈http://www.sciencedirect.com/science/article/pii/S0300908417300561〉. 〈10.1016/j.biochi.2017.03.004〉, Biochimie, Elsevier, 2017, 137, pp.78-87. ⟨10.1016/j.biochi.2017.03.004⟩
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- IF 3.112; International audience; Obesity is a worldwide problem, and dietary lipids play an important role in its pathogenesis. Recently, Erk1 knock-out (ERK1(-/-)) mice have been shown to exhibit low preference for dietary fatty acids. Hence, we maintained Erk1(-/-) mice on a high-fat diet (HFD) to assess the implication of this mitogen-activated protein (MAP) kinase in obesity. The Erk1(-/-) mice, fed the HFD, were more obese than wild-type (WT) animals, fed the same diet. Erk1(-/-) obese mice gained more fat and liver mass than WT obese animals. No difference was observed in daily food and energy intake in HFD-fed both group of animals. However, feed efficiency was higher in Erk1(-/-) than WT animals. Blood cholesterol, triglyceride and insulin concentrations were higher in Erk1(-/-) obese mice compared to WT obese animals. Accordingly, homeostatic model assessment of insulin resistance (HOMA-IR) value was higher in Erk1(-/-) obese mice compared to WT obese animals. Interestingly, only Erk1(-/-) obese mice, but not WT-obese animals, exhibited high degree of phosphorylation of liver MEK, the upstream regulator of ERK1/2. This phenomenon was associated with high liver ERK2 phosphorylation in Erk1(-/-) obese mice which also had high liver acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FAS) mRNA expression, suggesting high lipogenesis in these animals. The Erk1(-/-) obese mice also had low PPAR-α and CPT1β mRNA, indicating low fatty acid oxidation. Our observations suggest that ERK1 and ERK2 might play key roles in the regulation of obesity.
- Subjects :
- Blood Glucose
Male
0301 basic medicine
medicine.medical_treatment
Mice, Obese
Biochemistry
Mice
chemistry.chemical_compound
Phosphorylation
Beta oxidation
Cells, Cultured
Mice, Knockout
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Reverse Transcriptase Polymerase Chain Reaction
General Medicine
Lipids
Fatty acid synthase
Liver
Lipogenesis
Homeostatic model assessment
medicine.medical_specialty
Blotting, Western
Biology
Diet, High-Fat
Real-Time Polymerase Chain Reaction
03 medical and health sciences
Insulin resistance
Internal medicine
medicine
Animals
[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology
RNA, Messenger
Obesity
[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology
Inflammation
Triglyceride
Insulin
Body Weight
Lipid Metabolism
medicine.disease
Mice, Inbred C57BL
030104 developmental biology
Endocrinology
chemistry
biology.protein
MAP kinase
Insulin Resistance
Subjects
Details
- ISSN :
- 03009084
- Volume :
- 137
- Database :
- OpenAIRE
- Journal :
- Biochimie
- Accession number :
- edsair.doi.dedup.....65e7111f268dcad13d0b40c69e90eee9