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The guanylate cyclase signaling system in zebrafish photoreceptors
- Source :
- FEBS Letters. 587:2055-2059
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Zebrafish express in the retina a large variety of three different membrane-bound guanylate cyclases and six different guanylate cyclase-activating proteins (zGCAPs) belonging to the family of neuronal calcium sensor proteins. Although these proteins are predominantly localized in rod and cone photoreceptor cells of the retina, they differ in their spatial-temporal expression profiles. Further, each zGCAP has a different affinity for Ca(2+) and displays different Ca(2+)-sensitivities of guanylate cyclase activation. Thus, zGCAPs operate as cytoplasmic Ca(2+)-sensors that sense incremental changes of cytoplasmic Ca(2+)-concentration in rod and cone cells and control the activity of their target guanylate cyclases in a Ca(2+)-relay mode fashion.
- Subjects :
- GUCY1B3
genetic structures
Biophysics
Guanylate cyclase-activating protein
Biochemistry
Structural Biology
Genetics
medicine
Animals
Humans
Molecular Biology
Zebrafish
Calcium signaling
Retina
GUCY1A2
Photoreceptor
biology
GUCY1A3
Cell Biology
Guanylate cyclase 2C
Zebrafish Proteins
Guanylate cyclase
biology.organism_classification
Guanylate Cyclase-Activating Proteins
Cell biology
Enzyme Activation
medicine.anatomical_structure
GUCY2D
sense organs
Photoreceptor Cells, Vertebrate
Subjects
Details
- ISSN :
- 00145793
- Volume :
- 587
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....65e58ee720ccd56972bf551d8feb3880