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Oxidative stress, antioxidant defences and aging
- Publication Year :
- 1998
-
Abstract
- Apoptosis and aging share common mechanisms in oxidative stress and mitochondrial involvement. Treatment of cultured neuroblastoma cells with a radical initiator induced apoptosis; raise in hydrogen peroxide and release of cytochrome c from mitochondria preceded collapse of mitochondrial potential and cell death. In rat hepatocytes treated with adriamycin incubation with exogenous Coenzyme Q10 counteracted the drug-induced increase of hydrogen peroxide and the fall of the mitochondrial potential, thus demonstrating the quinone antioxidant effect. Complex I activity and its rotenone sensitivity decreased in brain cortex non-synaptic mitochondria from old rats; a 5 kb mitochondrial DNA deletion was found only in the old rats. A similar behavior was found in human platelets from old individuals. The postulated energy decline was confirmed by the inhibitor sensitivities of platelet aggregation and lactate production. The lack of the 5 kb deletion in platelets throws doubts on mitochondrial DNA lesions as the only causes of mitochondrial dysfunction in aging.
- Subjects :
- Aging
medicine.medical_specialty
Programmed cell death
Mitochondrial DNA
Ubiquinone
Clinical Biochemistry
Apoptosis
Biology
Mitochondrion
medicine.disease_cause
Biochemistry
Antioxidants
chemistry.chemical_compound
Internal medicine
medicine
Animals
Humans
Coenzyme Q10
Cytochrome c
General Medicine
Rotenone
Rats
Oxidative Stress
Endocrinology
chemistry
biology.protein
Molecular Medicine
Oxidative stress
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....65e25e972db9272e88cc42d08afee182