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Estrogen receptor ß is involved in the anorectic action of estrogen
- Source :
- International Journal of Obesity. 26:1103-1109
- Publication Year :
- 2002
- Publisher :
- Springer Science and Business Media LLC, 2002.
-
Abstract
- OBJECTIVE: Estrogen has been implicated in feeding behavior and adiposity. This study was undertaken to elucidate the mechanism underlying the anti-obesity and anorectic action of estrogen and the role of estrogen receptor (ER) in the central nervous system. METHODS AND RESULTS: Ovariectomy in 8-week-old female Wistar rats induced hyperphagia along with an increase in body weight and abdominal fat accumulation compared to control sham-operated rats. These changes were fully reversed by subcutaneous replacement of estradiol and were abrogated by pair-feeding. Then, the effects of intracerebroventricular infusion of estradiol, alone or in combination with antisense oligodeoxynucleotides (ODN), for ER in ovariectomized rats were examined. The estradiol group showed 10–20% lower daily food intake, and after the 2-week infusion period a 14% reduction in body weight with a similar reduction in abdominal fat compared to the vehicle group. The inhibitory effect of estradiol on food intake and body weight was blocked by co-administration of ER-s antisense ODN, whereas ER-α antisense ODN did not show any influence. CONCLUSION: These results indicate that ER-s in the central nervous system is involved in the anorectic action of estrogen.
- Subjects :
- medicine.medical_specialty
medicine.drug_class
Ovariectomy
Endocrinology, Diabetes and Metabolism
Central nervous system
Medicine (miscellaneous)
Adipose tissue
Estrogen receptor
Drug Administration Schedule
Oligodeoxyribonucleotides, Antisense
Eating
Internal medicine
medicine
Animals
Estrogen Receptor beta
Obesity
Rats, Wistar
Estrogen receptor beta
Injections, Intraventricular
Nutrition and Dietetics
Estradiol
business.industry
Body Weight
Brain
Rats
Endocrinology
medicine.anatomical_structure
Adipose Tissue
Receptors, Estrogen
Mechanism of action
Estrogen
Anorectic
Ovariectomized rat
Female
medicine.symptom
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 14765497 and 03070565
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- International Journal of Obesity
- Accession number :
- edsair.doi.dedup.....65cc820b65bd798c408a9001d162469a