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SARS-CoV-2 infection in patients with β-thalassemia: The French experience

Authors :
Imane Agouti
Laurent Pascal
Gonzalo De Luna
Isabelle Thuret
Estelle Jean-Mignard
Source :
Transfusion Clinique et Biologique
Publication Year :
2021
Publisher :
Société française de transfusion sanguine (SFTS). Published by Elsevier Masson SAS., 2021.

Abstract

INTRODUCTION: Because of iron overload complications, thrombosis and infectious predisposition, patients with severe forms of thalassemia are likely to be at increased risk of COVID-19 complications. RESULTS: A national survey conducted during the year 2020 across the French reference centers for hemoglobinopathies identified 16 cases of COVID-19 confirmed by RT-PCR in beta-thalassemia patients. Their age ranged from 11 months to 60 years. 15 patients were transfusion-dependent and 6 were splenectomized. Concerning iron overload related complications, none had diabetes or cirrhosis and only one had experienced heart failure. All 4 pediatric patients were pauci-symptomatic during the viral episode. Three patients (41, 49 and 57 years old) developed COVID-19 pneumonia requiring oxygen therapy without the need for mechanical ventilation. Neutropenia (absolute neutrophils count

Details

Language :
English
ISSN :
19538022 and 12467820
Database :
OpenAIRE
Journal :
Transfusion Clinique et Biologique
Accession number :
edsair.doi.dedup.....65c2bb308f9a6a4c0159e2dc0ac281e0