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SARS-CoV-2 infection in patients with β-thalassemia: The French experience
- Source :
- Transfusion Clinique et Biologique
- Publication Year :
- 2021
- Publisher :
- Société française de transfusion sanguine (SFTS). Published by Elsevier Masson SAS., 2021.
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Abstract
- INTRODUCTION: Because of iron overload complications, thrombosis and infectious predisposition, patients with severe forms of thalassemia are likely to be at increased risk of COVID-19 complications. RESULTS: A national survey conducted during the year 2020 across the French reference centers for hemoglobinopathies identified 16 cases of COVID-19 confirmed by RT-PCR in beta-thalassemia patients. Their age ranged from 11 months to 60 years. 15 patients were transfusion-dependent and 6 were splenectomized. Concerning iron overload related complications, none had diabetes or cirrhosis and only one had experienced heart failure. All 4 pediatric patients were pauci-symptomatic during the viral episode. Three patients (41, 49 and 57 years old) developed COVID-19 pneumonia requiring oxygen therapy without the need for mechanical ventilation. Neutropenia (absolute neutrophils count
- Subjects :
- medicine.medical_specialty
Cirrhosis
Iron Overload
Thalassemia
Clinical Biochemistry
Population
Neutropenia
Hydroxycarbamide
chemistry.chemical_compound
Internal medicine
medicine
Humans
Adverse effect
education
Child
education.field_of_study
business.industry
SARS-CoV-2
Biochemistry (medical)
beta-Thalassemia
COVID-19
Infant
Hematology
Middle Aged
medicine.disease
Pneumonia
chemistry
Original Article
Deferiprone
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 19538022 and 12467820
- Database :
- OpenAIRE
- Journal :
- Transfusion Clinique et Biologique
- Accession number :
- edsair.doi.dedup.....65c2bb308f9a6a4c0159e2dc0ac281e0