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Association of SNPs in CDKN2A (P14ARF) Tumour Suppressor Gene With Endometrial Cancer in Postmenopausal Women
- Source :
- In Vivo. 34:943-951
- Publication Year :
- 2020
- Publisher :
- Anticancer Research USA Inc., 2020.
-
Abstract
- Background/Aim: This research was aimed to evaluate the association between three selected single nucleotide polymorphisms (SNPs) within the CDKN2A (P14ARF) tumour suppressor gene and the incidence of endometrial cancer (EC) in postmenopausal women. Patients and Methods: The study included 194 postmenopausal women; 144 with EC and 50 non-cancer controls. Genotypes in P14ARF rs3088440, rs3731217 and rs3731245 polymorphisms were assayed using PCR-RFLP and confirmed by sequencing. Results: Regarding the rs3088440 polymorphism, CT, and CT-TT genotypes, were more prevalent among EC patients than in controls (OR=5.55, p=0.023, OR=5.29, p=0.027; and OR=2.92, p=0.023, respectively). The T allele within rs3088440 was more prevalent in EC females than in controls (χ(2)=4.7, p=0.030). Considering rs3731217, TG and TG-GG genotypes were less prevalent among EC (OR=0.34, p=0.024 or p=0.023; and OR=0.38, p=0.035, respectively). Conclusion: Polymorphisms in the CDKN2A gene are associated with EC in postmenopausal women.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Genotype
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
General Biochemistry, Genetics and Molecular Biology
p14arf
CDKN2A
Internal medicine
Tumor Suppressor Protein p14ARF
Biomarkers, Tumor
Humans
Medicine
Genetic Predisposition to Disease
Tumour suppressor gene
Allele
Alleles
Genetic Association Studies
Aged
Neoplasm Staging
Pharmacology
Postmenopausal women
business.industry
Endometrial cancer
Sequence Analysis, DNA
Middle Aged
medicine.disease
Endometrial Neoplasms
Gene Expression Regulation, Neoplastic
Postmenopause
Alternative Splicing
Female
business
Research Article
Subjects
Details
- ISSN :
- 17917549 and 0258851X
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- In Vivo
- Accession number :
- edsair.doi.dedup.....65bea19ca1bf2cdcf34c85cef0ce3b93