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Evidence for hormonal control of heart regenerative capacity during endothermy acquisition
- Source :
- Science, Science, American Association for the Advancement of Science, 2019, pp.eaar2038. ⟨10.1126/science.aar2038⟩, Circ Res, Science, 2019, pp.eaar2038. ⟨10.1126/science.aar2038⟩, Science, American Association for the Advancement of Science, 2019, 364 (6436), pp.184-188. ⟨10.1126/science.aar2038⟩, Science (New York, N.Y.), vol 364, iss 6436
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- The price of staying warm Among vertebrates, zebrafish and salamanders can regenerate their hearts, whereas adult mice and humans cannot. Hirose et al. analyzed diploid cardiomyocyte frequency as a proxy for cardiac regenerative potential across 41 vertebrate species (see the Perspective by Marchianò and Murry). They observed an inverse correlation of these cells with thyroid hormone concentrations during the ectotherm-to-endotherm transition. Mice with defects in thyroid hormone signaling retained significant heart regenerative capacity, whereas zebrafish exposed to excessive thyroid hormones exhibit impaired cardiac repair. Loss of heart regenerative ability in mammals may represent a trade-off for increases in metabolism necessary for the development of endothermy. Science , this issue p. 184 ; see also p. 123
- Subjects :
- 0301 basic medicine
Adult Newt
[SDV]Life Sciences [q-bio]
Proliferation
030204 cardiovascular system & hematology
Cardiovascular
Regenerative Medicine
Mice
[SPI]Engineering Sciences [physics]
0302 clinical medicine
Receptors
Thyroid Hormone
2.1 Biological and endogenous factors
Myocyte
Myocytes, Cardiac
Aetiology
Receptor
Zebrafish
Phylogeny
Multidisciplinary
Receptors, Thyroid Hormone
Thyroid
Temperature
Heart
Lizards
Cell biology
Cardiovascular physiology
Heart Disease
medicine.anatomical_structure
Signal transduction
Cardiac
Body Temperature Regulation
Signal Transduction
Thyroid Hormones
Consumption
General Science & Technology
Activation
Biology
Energy-expenditure
Article
Polyploidy
03 medical and health sciences
medicine
Animals
Regeneration
[INFO]Computer Science [cs]
Cell Proliferation
Myocytes
Regeneration (biology)
Cell Cycle Checkpoints
biology.organism_classification
Diploidy
Recombination
030104 developmental biology
Metabolic-rate
Hormone
Subjects
Details
- Language :
- English
- ISSN :
- 00368075 and 10959203
- Database :
- OpenAIRE
- Journal :
- Science, Science, American Association for the Advancement of Science, 2019, pp.eaar2038. ⟨10.1126/science.aar2038⟩, Circ Res, Science, 2019, pp.eaar2038. ⟨10.1126/science.aar2038⟩, Science, American Association for the Advancement of Science, 2019, 364 (6436), pp.184-188. ⟨10.1126/science.aar2038⟩, Science (New York, N.Y.), vol 364, iss 6436
- Accession number :
- edsair.doi.dedup.....65a1fb95b899c58786289a3d645dd715