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Emergence of a novel drug resistant H7N9 influenza virus: evidence based clinical potential of a natural IFN-α for infection control and treatment
- Source :
- Expert review of anti-infective therapy. 12(2)
- Publication Year :
- 2013
-
Abstract
- The novel avian H7N9 influenza virus has caused more than 130 human infections with 43 deaths (as of September, 2013) in China. Because of the lack of existing immunity against H7 subtype influenza viruses in the human population and the absence of a licensed commercial vaccine, antiviral drugs are critical tools for the treatment of infection with this novel H7N9. Both M2-ion channel blockers and neuraminidase inhibitors are used as antiviral drugs for influenza infections of humans. The emerging H7N9 viruses are resistant to the M2-ion channel blockers because of a S31N mutation in the M2 protein; additionally, some H7N9 isolates have gained neuraminidase R292K substitution resulting in broad resistance to neuraminidase inhibitors. In this study we report that Alferon N can inhibit wild type and 292K H7N9 viruses replication in vitro. Since Alferon N is approved for clinical use, this would allow a rapid regulatory approval process for this drug under pandemic threat.
- Subjects :
- Microbiology (medical)
Drug
medicine.drug_class
media_common.quotation_subject
Population
Neuraminidase
Drug resistance
Influenza A Virus, H7N9 Subtype
Virus Replication
Microbiology
Antiviral Agents
Virus
Cell Line
Madin Darby Canine Kidney Cells
Viral Matrix Proteins
Dogs
Oseltamivir
Immunity
Virology
Membrane Transport Modulators
Pandemic
Drug Resistance, Viral
Influenza, Human
medicine
Animals
Humans
Immunologic Factors
Enzyme Inhibitors
education
media_common
education.field_of_study
biology
Interferon-alpha
Infectious Diseases
Mutation
biology.protein
Antiviral drug
Subjects
Details
- ISSN :
- 17448336
- Volume :
- 12
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Expert review of anti-infective therapy
- Accession number :
- edsair.doi.dedup.....658bb8f60c3d5420bc7a6d392b8827f9