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Inflammatory effects of atazanavir/ritonavir versus darunavir/ritonavir in treatment naïve, HIV-1-infected patients
- Publication Year :
- 2018
-
Abstract
- Background: Limited studies have compared the impact of different antiretroviral regimens on soluble markers of inflammation with discordant results. Methods: In this prospective study, treatment naïve HIV-1-infected patients were included if they started their current regimen with atazanavir/ritonavir (ATV/r) (N = 73, Group 1) or darunavir/ritonavir (DRV/r) (N = 85, Group 2) plus tenofovir/emtricitabine. The analysis of IL-6, MCP-1, sCD163, VCAM-1, ox-LDL, and adiponectine was performed on two stored plasma samples, the first prior to antiretroviral therapy initiation and the second one year after initiation. Results: The results of our analysis show a difference in ox-LDL between the two groups with higher mean (SD) values in ATV/r based group 608.5 ± 137.4 versus 519.1 ± 119.6 in DRV/r group, after controlling for baseline levels of ox-LDL as well as other potential confounding factors controlled by means of matching design or linear regression modelling. Conclusions: Our analysis provides further data examining the association between the modulation of vascular inflammatory and of activation markers with specific protease inhibitors-based treatments over one year of exposure to these drugs. The data show little evidence for an association, supporting the notion that antiretroviral regimens has generally poor efficiency in downregulating these soluble markers.
- Subjects :
- 0301 basic medicine
Male
Vascular inflammation, activation markers,first-line antiretroviral therapy, atazanavir, darunavir, HIV
darunavir
HIV Infections
Gastroenterology
Therapy naive
0302 clinical medicine
immune system diseases
heterocyclic compounds
Pharmacology (medical)
activation markers
030212 general & internal medicine
Prospective Studies
Prospective cohort study
atazanavir
Vascular inflammation
Darunavir
Confounding
virus diseases
Middle Aged
first-line antiretroviral therapy
Infectious Diseases
Combination
Drug Therapy, Combination
Female
medicine.drug
Adult
medicine.medical_specialty
Anti-HIV Agents
HIV
Atazanavir Sulfate
Biomarkers
Humans
Inflammation
Ritonavir
HIV-1
Emtricitabine
NO
03 medical and health sciences
Drug Therapy
Internal medicine
parasitic diseases
medicine
business.industry
biochemical phenomena, metabolism, and nutrition
030112 virology
Atazanavir
Regimen
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....6570ea3ee917d17399443eb1d8437125