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Protective effect of hydrogen sulfide in a murine model of acute lung injury induced by combined burn and smoke inhalation
- Source :
- Clinical science (London, England : 1979). 115(3)
- Publication Year :
- 2008
-
Abstract
- Acute lung injury results in a severe inflammatory response, which leads to priming and activation of leucocytes, release of reactive oxygen and reactive nitrogen species, destruction of pulmonary endothelium, extravasation of protein-rich fluid into the interstitium and formation of oedema. Recently, H2S (hydrogen sulfide) has been shown to decrease the synthesis of pro-inflammatory cytokines, reduce leucocyte adherence to the endothelium and subsequent diapedesis of these cells from the microvasculature in in vivo studies, and to protect cells in culture from oxidative injury. In the present study, we hypothesized that a parenteral formulation of H2S would reduce the lung injury induced by burn and smoke inhalation in a novel murine model. H2S post-treatment significantly decreased mortality and increased median survival in mice. H2S also inhibited IL (interleukin)-1β levels and significantly increased the concentration of the anti-inflammatory cytokine IL-10 in lung tissue. Additionally, H2S administration attenuated protein oxidation following injury and improved the histological condition of the lung. In conclusion, these results suggest that H2S exerts protective effects in acute lung injury, at least in part through the activation of anti-inflammatory and antioxidant pathways.
- Subjects :
- Endothelium
Smoke inhalation
Interleukin-1beta
Drug Evaluation, Preclinical
Inflammation
Lung injury
Pharmacology
Protein oxidation
chemistry.chemical_compound
Mice
Medicine
Animals
Hydrogen Sulfide
Lung
Reactive nitrogen species
Respiratory Distress Syndrome
business.industry
General Medicine
Smoke Inhalation Injury
equipment and supplies
medicine.disease
Extravasation
Interleukin-10
Mice, Inbred C57BL
Disease Models, Animal
Oxidative Stress
medicine.anatomical_structure
chemistry
Immunology
Female
medicine.symptom
Inflammation Mediators
business
Burns
Subjects
Details
- ISSN :
- 14708736
- Volume :
- 115
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Clinical science (London, England : 1979)
- Accession number :
- edsair.doi.dedup.....656e0f365bcdf15a17ce566cdc77805b