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ε-Aminocaproic acid in angiographically negative subarachnoid hemorrhage patients is safe: a retrospective review of 83 consecutive patients
- Source :
- Neurosurgery. 70(3)
- Publication Year :
- 2011
-
Abstract
- Background:ε-Aminocaproic acid (EACA) has been used to reduce the rate of cerebral aneurysm rerupture before definitive treatment. In centers administering EACA to patients with a subarachnoid hemorrhage (SAH), patients eventually diagnosed with angiographically negative subarachnoid hemorrhage (ANSAH) may also initially receive EACA, perhaps placing them at increased risk for ischemic complications.Objective:To evaluate the effect of short-term EACA on outcomes and secondary measures in patients with ANSAH.Methods:We conducted a retrospective study of 454 consecutive SAH patients over a 2-year period under a current protocol for EACA use. Patients were excluded if a source for the SAH was discovered, yielding a total of 83 ANSAH patients. The patients were assigned to groups that did or did not receive EACA. The primary end points of the study were ischemic complications, pulmonary emboli, vasospasm, ventriculoperitoneal shunting rates, and outcomes.Results:Statistical analysis yielded no significant difference between the 2 arms with respect to any of the end points: vasospasm (P = .65), deep vein thrombosis (P = .51), pulmonary embolism (P = 1.0), stroke (P = 1.0), myocardial infarction (P = 1.0), and ventriculoperitoneal shunt (P = .57). There was no statistically significant outcome difference using the modified Rankin Scale (P = .30).Conclusion:Short-term (
- Subjects :
- Adult
Male
medicine.medical_specialty
Subarachnoid hemorrhage
Deep vein
Brain Ischemia
Modified Rankin Scale
Risk Factors
Antifibrinolytic agent
medicine
Secondary Prevention
Humans
Vasospasm, Intracranial
cardiovascular diseases
Stroke
Retrospective Studies
business.industry
Vasospasm
Middle Aged
Subarachnoid Hemorrhage
medicine.disease
Thrombosis
Antifibrinolytic Agents
Surgery
Pulmonary embolism
Cerebral Angiography
medicine.anatomical_structure
Treatment Outcome
Anesthesia
Case-Control Studies
Aminocaproic Acid
Female
Neurology (clinical)
business
Subjects
Details
- ISSN :
- 15244040
- Volume :
- 70
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Neurosurgery
- Accession number :
- edsair.doi.dedup.....656a4f981c52f7466e1c522d95c9d724