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The Endocannabinoid System as a Therapeutic Target in Glaucoma
- Source :
- Neural Plasticity, Neural Plasticity, Vol 2016 (2016)
- Publication Year :
- 2015
-
Abstract
- Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss. Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder. The endocannabinoid system (ECS) has attracted considerable attention as a potential target for the treatment of glaucoma, largely due to the observed IOP lowering effects seen after administration of exogenous cannabinoids. However, recent evidence has suggested that modulation of the ECS may also be neuroprotective. This paper will review the use of cannabinoids in glaucoma, presenting pertinent information regarding the pathophysiology of glaucoma and how alterations in cannabinoid signalling may contribute to glaucoma pathology. Additionally, the mechanisms and potential for the use of cannabinoids and other novel agents that target the endocannabinoid system in the treatment of glaucoma will be discussed.
- Subjects :
- 0301 basic medicine
Intraocular pressure
genetic structures
medicine.medical_treatment
Glaucoma
Disease
Review Article
Neuroprotection
lcsh:RC321-571
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Humans
Receptors, Cannabinoid
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Intraocular Pressure
Cannabinoid Receptor Agonists
business.industry
Cannabinoids
medicine.disease
Endocannabinoid system
Pathophysiology
eye diseases
3. Good health
030104 developmental biology
medicine.anatomical_structure
Neuroprotective Agents
Neurology
Retinal ganglion cell
lipids (amino acids, peptides, and proteins)
Neurology (clinical)
Cannabinoid
sense organs
business
Neuroscience
030217 neurology & neurosurgery
Endocannabinoids
Signal Transduction
Subjects
Details
- ISSN :
- 16875443
- Volume :
- 2016
- Database :
- OpenAIRE
- Journal :
- Neural plasticity
- Accession number :
- edsair.doi.dedup.....6557c4728cd3372c708c6ad8819762a7