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The value of adjuvant chemotherapy in stage II/III colorectal signet ring cell carcinoma
- Source :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- This study aimed to assess the benefit of postoperative adjuvant chemotherapy in stage II–III colorectal signet ring cell carcinoma (SRCC). Qualified postoperative patients were extracted from Surveillance, Epidemiology, and End Results (SEER) database from 2004 until 2015. We collected 1675 patients in the research, and 936 patients were subjected to adjuvant chemotherapy group. The proportions of married status, male, rectal cancer, grade III/IV, AJCC stage III and radiotherapy were higher; While, the rates of white race, ≥ 65 years old and located in cecum–transverse colon were lower in patients of chemotherapy group compared to no chemotherapy group (all P P P = 0.93). However, after adjusting for confounding factors by multivariable Cox regression analysis, receipt of postoperative chemotherapy was still associated with better CSS and OS (CSS: hazard ratio [HR] = 0.719, 95% CI 0.612–0.844, P P
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Databases, Factual
Colorectal cancer
medicine.medical_treatment
lcsh:Medicine
Colorectal Signet Ring Cell Carcinoma
Gastroenterology
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Carcinoma
Humans
Postoperative Period
Stage (cooking)
lcsh:Science
Cecum
Survival analysis
Cancer
Aged
Neoplasm Staging
Chemotherapy
Multidisciplinary
business.industry
lcsh:R
Hazard ratio
medicine.disease
Prognosis
Survival Analysis
Radiation therapy
030104 developmental biology
Oncology
Risk factors
Chemotherapy, Adjuvant
lcsh:Q
Female
business
Colorectal Neoplasms
Carcinoma, Signet Ring Cell
030217 neurology & neurosurgery
Colon, Transverse
SEER Program
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....655560bec315ab9a5cbe6321c8532432