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Interferon-free therapy with sofosbuvir plus ribavirin for successful treatment of genotype 2 hepatitis C virus with lichen planus: a case report
- Source :
- Clinical Journal of Gastroenterology. 10:270-273
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Hepatitis C virus (HCV) infection remains the main cause of liver disease and can lead to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HCV may also develop extrahepatic manifestations in the skin, eyes, joints, kidneys, nervous system, and immune system. In fact, several studies reported that up to 70% of HCV patients experienced extrahepatic manifestations. Lichen planus (LP), which is an immune system disorder that is triggered by viral infections, allergens, and stress, can affect the skin, mouth, nails, and scalp. The association of LP with HCV has been reported, but the effect of HCV treatment on LP remission is controversial. We encountered a 53-year-old man with HCV genotype 2a and LP that were successfully treated with sofosbuvir and ribavirin for 12 weeks. After treatment, he achieved sustained virological response against HCV and remission of erosive LP lesions on the lip. In the era of interferon (IFN)-based treatment for HCV, exacerbation of autoimmune diseases is a common adverse event. Therefore, use of an IFN-free regimen of direct-acting antivirals for HCV might prevent the extrahepatic manifestation of an immune disorder.
- Subjects :
- Male
Genotype
Sofosbuvir
Hepatitis C virus
Hepacivirus
medicine.disease_cause
Antiviral Agents
03 medical and health sciences
Liver disease
chemistry.chemical_compound
0302 clinical medicine
Ribavirin
medicine
Humans
biology
business.industry
Lichen Planus
Gastroenterology
virus diseases
Lip Diseases
General Medicine
Hepatitis C
Middle Aged
medicine.disease
biology.organism_classification
Lip
digestive system diseases
chemistry
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Immunology
Drug Therapy, Combination
030211 gastroenterology & hepatology
Immune disorder
business
medicine.drug
Subjects
Details
- ISSN :
- 18657265 and 18657257
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Clinical Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....6553bd58f392673bf611256511de3355