The Role of Mitomycin in the Prevention and Treatment of Scar Formation in the Pediatric Aerodigestive Tract

Objective To evaluate the role of mitomycin in the prevention and treatment of scar formation in the pediatric aerodigestive tract. Design Prospective study; institutional review board–approved clinical trial. Setting Tertiary care pediatric medical center. Patients Fifteen patients; choanal atresia in 5 patients, airway stenosis in 8 patients, hypopharyngeal stenosis in 1 patient, and esophageal stenosis in 1 patient. Outcome The efficacy and safety of mitomycin in the prevention of scar formation. Intervention All patients underwent surgical repair of the stenotic area, followed by topical application of mitomycin (1 mL of 0.4 mg/mL) for 4 minutes. Results Ten patients (67%) showed major improvement, 4 patients (27%) showed minor improvement, and 1 patient (7%) showed no improvement. Conclusion Topical application of mitomycin can play an effective role in the prevention and treatment of scar formation in the aerodigestive tract.