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A randomized study of the effects of adenine arabinoside 5′-monophosphate (short or long courses) and lymphoblastoid interferon on hepatitis B virus replication
- Source :
- Hepatology. 5:1132-1138
- Publication Year :
- 1985
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1985.
-
Abstract
- A previous randomized controlled study has shown a 30% rate of HBe antigen/antibody seroconversion within 1 year of a month course of adenine arabinoside-5'-monophosphate; no seroconversion occurred in the control group. In this study of patients derived from the same population, 45 hepatitis B virus carriers with chronic liver disease were randomized to receive either a short (4-week) course of adenine arabinoside-5'-monophosphate, a long (7 to 8-week) course of adenine arabinoside-5'-monophosphate or a 12-week course of lymphoblastoid interferon. Long-lasting suppression of hepatitis B virus replication with disappearance of serum hepatitis B virus DNA and clearance of HBeAg occurred within 12 months of treatment in four patients who received the short course of adenine arabinoside-5'-monophosphate and in five who received interferon. Of the nine responders, four also lost HBsAg. A response to antiviral therapy was accompanied by clinical and biochemical evidence of improvement in liver disease. None of the patients who received a long course of adenine arabinoside-5'-monophosphate responded. Peripheral neuropathy and myalgia were the most serious adverse effect affecting three recipients of the short course of adenine arabinoside-5'-monophosphate and eight recipients of the long course. Thrice weekly administration of interferon was well-tolerated. Further studies to identify the characteristics of the "responder patients" and large-scale controlled trials of antiviral therapy in these subgroups are indicated.
- Subjects :
- Adult
Male
Hepatitis B virus
HBsAg
Time Factors
Fever
Population
Virus Replication
medicine.disease_cause
Chronic liver disease
Drug Administration Schedule
Random Allocation
Liver disease
Interferon
Humans
Medicine
Aspartate Aminotransferases
Seroconversion
education
Fatigue
education.field_of_study
Arabinonucleotides
Hepatology
business.industry
Peripheral Nervous System Diseases
Hepatitis B
medicine.disease
HBeAg
Carrier State
DNA, Viral
Interferon Type I
Immunology
Female
business
Vidarabine Phosphate
medicine.drug
Subjects
Details
- ISSN :
- 15273350 and 02709139
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Hepatology
- Accession number :
- edsair.doi.dedup.....65400ba8f44ab841d584f40c8030fbe2