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Early‐life exposures to infectious agents and later cancer development
- Source :
- Cancer Medicine
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- There is a growing understanding that several infectious agents are acquired in early life and this is the reason why available vaccines target the new born, infants, and adolescents. Infectious agents are associated with cancer development and it is estimated that about 20% of the world's cancer burden is attributed to infectious agents. There is a growing evidence that certain infectious agents acquired in early life can give rise to cancer development, but estimates of the cancer burden from this early‐life acquisition is unknown. In this article, we have selected five cancers (cervical, liver, Burkitt's lymphoma‐leukemia, nasopharyngeal carcinoma, and adult T‐cell leukemia‐lymphoma) and examine their links to infectious agents (HPV, HBV, HCV, EBV, and HTLV‐1) acquired in early life. For these agents, the acquisition in early life is from mother‐to‐child transmission, perinatal contact (with genital tract secretions, amniotic fluids, blood, and breast milk), saliva, sexual intercourse, and blood transfusion. We also discuss prevention strategies, address future directions, and propose mechanisms of action after a long latency period from the time of acquisition of the infectious agent in early life to cancer development.
- Subjects :
- Male
Cancer Research
Pediatrics
medicine.medical_specialty
Review
Infections
Neoplasms
infectious agents
medicine
Humans
Radiology, Nuclear Medicine and imaging
Cancer
Cervical cancer
Infection Control
Maternal Transmission
Transmission (medicine)
business.industry
Age Factors
Environmental Exposure
Environmental exposure
Hepatitis C
Hepatitis B
medicine.disease
Cell Transformation, Neoplastic
Oncology
Host-Pathogen Interactions
Immunology
perinatal transmission
Female
early life exposure
Liver cancer
business
Cancer Prevention
Subjects
Details
- ISSN :
- 20457634
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....6539e2a8069edc38dc0af9e168791ec2