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Evidence for bisphenol A-induced disruption of maternal thyroid homeostasis in the pregnant ewe at low level representative of human exposure
- Source :
- Chemosphere, Chemosphere, Elsevier, 2017, 182, pp.458-467. ⟨10.1016/j.chemosphere.2017.05.028⟩, Chemosphere (182), 458-467. (2017)
- Publication Year :
- 2017
- Publisher :
- HAL CCSD, 2017.
-
Abstract
- Many uncertainties remain regarding the potential of bisphenol A (BPA) as a thyroid disruptor in mammals and the relevance of experimental data to humans. The relevance of the exposure schemes used in experimental in vivo studies is also a major source of uncertainty when analysing the risk of BPA exposure for human health. In this context, the goals of our study, conducted in an ovine model relevant to human gestation and thyroid physiologies, were to: 1) determine the equivalence of subcutaneous and dietary exposures and 2) determine if environmentally relevant doses of BPA can alter gestational and newborn thyroid functions. The difference between the two routes of exposure was mainly related to the overall BPA exposure and much less to the peak serum concentrations. Interestingly, BPA-GLUC (the main metabolite of BPA) internal exposure via both routes was almost identical. The decrease in thyroid hormones concentration overtime was more accentuated in ewes treated with BPA, particularly with the medium dose (50 μg/(kg.d); SC) for which the maximum BPA concentrations were predicted to be within the 1-10 ng/mL range i.e. very similar to the highest blood concentrations reported in humans. The balance between TT4 and rT3 varied differently between the vehicle and the medium dose group. The mechanisms underlying those modifications of maternal thyroid homeostasis remain to be determined. Our study did not evidence significant modification of TSH secretion or binding to serum proteins but might suggest an effect at the level of deiodinases.
- Subjects :
- Male
0301 basic medicine
Bisphenol A
Health, Toxicology and Mutagenesis
Metabolite
[SDV]Life Sciences [q-bio]
Thyroid Gland
ovine model
Endocrine Disruptors
Thyroid Function Tests
010501 environmental sciences
human health
01 natural sciences
chemistry.chemical_compound
toxicokinetics
Homeostasis
Thyroid
thyroid disruption
General Medicine
santé humaine
Fetal Blood
Pollution
Blood proteins
toxicokinetic
3. Good health
medicine.anatomical_structure
Maternal Exposure
Gestation
Environmental Pollutants
Female
pregnancy
hormones, hormone substitutes, and hormone antagonists
Thyroid Hormones
medicine.medical_specialty
endocrine system
bisphenol A
exposure
Environmental Engineering
Context (language use)
03 medical and health sciences
Glucuronides
Phenols
gestation
In vivo
Internal medicine
medicine
Animals
Humans
Environmental Chemistry
bisphénol a
Benzhydryl Compounds
0105 earth and related environmental sciences
Sheep
business.industry
urogenital system
thyroid function
Public Health, Environmental and Occupational Health
General Chemistry
toxicocinétique
030104 developmental biology
Endocrinology
chemistry
fonction thyroidienne
mécanisme de transmission
expérimentation ovine
business
Subjects
Details
- Language :
- English
- ISSN :
- 00456535
- Database :
- OpenAIRE
- Journal :
- Chemosphere, Chemosphere, Elsevier, 2017, 182, pp.458-467. ⟨10.1016/j.chemosphere.2017.05.028⟩, Chemosphere (182), 458-467. (2017)
- Accession number :
- edsair.doi.dedup.....65373a7af83e2b2f71aada7d6ba23ba2