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Sodium Fluoride Treatment is a Major Protector Against Vertebral and Nonvertebral Fractures When Compared with Other Common Treatments of Osteoporosis: A Longitudinal, Observational Study
- Source :
- Calcified Tissue International. 60:250-254
- Publication Year :
- 1997
- Publisher :
- Springer Science and Business Media LLC, 1997.
-
Abstract
- In a 5-year observational study we have compared sodium fluoride (NaF) with different treatments commonly used in the treatment of osteoporosis: calcium, estrogens, androgens, and calcitonin, referred to as non-NaF. We have looked at the incidence of vertebral and nonvertebral fractures. At baseline, the NaF group, consisting of 125 patients (89% females) aged 65 +/- 10 (X +/- SE) had more crush fractures (P0.0001) and more months since menopause (P = 0.004) than the non-NaF group, consisting of 127 patients (90% females) aged 63 +/- 10. Fractures were evaluated by X-ray. The entire follow-up of patients treated with NaF accounted for 361 person-years, of whom 43 patients suffered one or more new vertebral fractures (68 vertebral fractures in total) and 18 patients suffered one or more new nonvertebral fractures (22 complete peripheral fractures in total); follow-up of patients treated with non-NaF regimes accounted for 382 person-years, of whom 53 patients suffered one or more new vertebral fractures (69 vertebral fractures in total) and 20 patients suffered one or more new nonvertebral fractures (27 complete peripheral fractures in total). After adjusting for significant covariates at baseline, NaF proved to be a significant protector for vertebral fractures [odds ratio (OR) 0.48, 95% confidence interval (CI) 0.2-0.9], and for peripheral fractures (QR 0.41, 95% CI 0.2-0.9). On the other hand, the probability of suffering undesired effects was much higher with NaF treatment (OR 5.04, 95% CI 2.1-11.9). We conclude that in the treatment of osteoporosis, NaF has a protective effect against vertebral and nonvertebral fractures, does not increase the risk of femoral fractures, but has a higher incidence of untoward symptomatology.
- Subjects :
- Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Osteoporosis
Administration, Oral
Fractures, Bone
chemistry.chemical_compound
Endocrinology
Risk Factors
Sodium fluoride
medicine
Humans
Orthopedics and Sports Medicine
Longitudinal Studies
Aged
business.industry
Incidence (epidemiology)
Odds ratio
Middle Aged
medicine.disease
Confidence interval
Surgery
body regions
Menopause
chemistry
Calcitonin
Orthopedic surgery
Sodium Fluoride
Spinal Fractures
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 14320827 and 0171967X
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Calcified Tissue International
- Accession number :
- edsair.doi.dedup.....652f371f10d02514cef3626e1175800c