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Translational approach to understanding momentary factors associated with alcohol consumption
- Source :
- Br J Pharmacol
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Multiple interindividual and intra‐individual factors underlie variability in drinking motives, challenging clinical translatability of animal research and limiting treatment success of substance use‐related problems. Intra‐individual variability refers to time‐dependent continuous and discrete changes within the individual and in substance use research is studied as momentary variation in the internal states (craving, stressed, anxious, impulsive and tired) and response to external triggers (stressors, drug‐associated environmental cues and social encounters). These momentary stimuli have a direct impact on behavioural decisions and may be triggers and predictors of substance consumption. They also present potential targets for real‐time behavioural and pharmacological interventions. In this review, we provide an overview of the studies demonstrating different momentary risk factors associated with increased probability of alcohol drinking in humans and changes in alcohol seeking and consumption in animals. The review also provides an overview of pharmacological interventions related to every individual risk factor.
- Subjects :
- 0301 basic medicine
Pharmacology
Consumption (economics)
Motivation
Alcohol Drinking
Drinking motives
Stressor
Craving
Anxiety
Individual risk
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Pharmacological interventions
medicine
Humans
Cues
medicine.symptom
Substance use
Psychology
Review Articles
Alcohol consumption
030217 neurology & neurosurgery
Clinical psychology
Subjects
Details
- ISSN :
- 14765381 and 00071188
- Volume :
- 177
- Database :
- OpenAIRE
- Journal :
- British Journal of Pharmacology
- Accession number :
- edsair.doi.dedup.....652d031eda4d191fafcd08e92438ed77