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Urine Specific Gravity and the Accuracy of Urinalysis
- Source :
- Pediatrics. 144(5)
- Publication Year :
- 2019
-
Abstract
- BACKGROUND: A recent study in young infants found that different cutoffs maximized the accuracy of the urine white blood cell count in dilute versus concentrated urine samples. We aimed to confirm this finding and to determine its impact on clinical care. METHODS: We conducted a retrospective analysis of data gathered on consecutive children RESULTS: We included 10 078 children. The ability to rule in UTI (as measured by the positive likelihood ratio [LR]) was similar in dilute and concentrated urine for the leukocyte esterase test (11.76 vs 10.71, respectively). The positive LR for urine white blood cell count per high-powered field was higher in dilute urine (9.83 vs 6.12). In contrast, the positive LR for the nitrite test was lower in dilute urine (20.54 vs 47.44). Despite these differences, we found little change in the number of children treated with antibiotics in predictive models that took urine SG into consideration. CONCLUSIONS: Although we found that urine SG influences the accuracy of some components of the urinalysis, its inclusion in the decision-making process had negligible effect on the clinical care of children with UTI.
- Subjects :
- Male
medicine.medical_specialty
Urinalysis
Bacteriuria
Urology
Urine
Likelihood ratios in diagnostic testing
03 medical and health sciences
Leukocyte Count
0302 clinical medicine
030225 pediatrics
White blood cell
medicine
Humans
Pyuria
Specific Gravity
Retrospective Studies
Likelihood Functions
medicine.diagnostic_test
business.industry
Urine specific gravity
Infant
Retrospective cohort study
Leukocyte esterase
Nitrite test
medicine.anatomical_structure
Pediatrics, Perinatology and Child Health
Urinary Tract Infections
Female
business
Subjects
Details
- ISSN :
- 10984275
- Volume :
- 144
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Pediatrics
- Accession number :
- edsair.doi.dedup.....651b44dc0027cae819d3c8a0ed2e5901