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Columnar distribution of serotonin-dependent plasticity within kitten striate cortex
- Publication Year :
- 2000
- Publisher :
- The National Academy of Sciences, 2000.
-
Abstract
- Recent studies have identified the potential for an important role for serotonin (5-HT) receptors in the developmental plasticity of the kitten visual cortex. 5-HT 2C receptors are transiently expressed in a patchy fashion in the visual cortex of kittens between 30–80 days of age complementary to patches demarcated by cytochrome oxidase staining. 5-HT, operating via 5-HT 2C receptors, increases cortical synaptic plasticity as assessed both in brain slices and in vivo . Herein, we report that bath application of 5-HT substantially increases the probability of long-term potentiation within 5-HT 2C receptor-rich zones of cortex, but this effect is not observed in the 5-HT 2C receptor-poor zones. Instead, in these zones, 5-HT application increases the probability of long-term depression. These location-specific effects of 5-HT may promote the formation of compartment-specific cortical responses.
- Subjects :
- Serotonin
Long-Term Potentiation
Biology
Kitten
Electron Transport Complex IV
biology.animal
Cortex (anatomy)
Neuroplasticity
medicine
Receptor, Serotonin, 5-HT2C
Animals
Visual Cortex
Multidisciplinary
Neuronal Plasticity
Depression
Age Factors
Excitatory Postsynaptic Potentials
Long-term potentiation
Anatomy
Biological Sciences
Electric Stimulation
Visual cortex
medicine.anatomical_structure
Receptors, Serotonin
Synaptic plasticity
Acetylcholinesterase
Cats
Developmental plasticity
Neuroscience
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....651a08c9fd803163f7670df4631a254b