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Arresting chromosome replication upon energy starvation in Escherichia coli
- Source :
- Current Genetics, Charbon, G, Frimodt-Møller, J & Løbner-Olesen, A 2021, ' Arresting chromosome replication upon energy starvation in Escherichia coli ', Current Genetics, vol. 67, no. 6, pp. 877-882 . https://doi.org/10.1007/s00294-021-01202-2
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Most organisms possess several cell cycle checkpoints to preserve genome stability in periods of stress. Upon starvation, the absence of chromosomal duplication in the bacterium Escherichia coli is ensured by holding off commencement of replication. During normal growth, accumulation of the initiator protein DnaA along with cell cycle changes in its activity, ensure that DNA replication starts only once per cell cycle. Upon nutrient starvation, the prevailing model is that an arrest in DnaA protein synthesis is responsible for the absence of initiation. Recent indications now suggest that DnaA degradation may also play a role. Here we comment on the implications of this potential new layer of regulation.
- Subjects :
- DARS2
DNA Replication
DnaA
Cell cycle checkpoint
DNAA PROTEIN
medicine.disease_cause
Genomic Instability
Adenosine Triphosphate
Bacterial Proteins
Genome stability
BINDING
Gene duplication
Escherichia coli
Chromosome replication
Genetics
medicine
Cellular Energy Status
CYCLE
Starvation
biology
DNA replication
General Medicine
Chromosomes, Bacterial
Mini-Review
Cell cycle
biology.organism_classification
ATP HYDROLYSIS
Cell biology
DNA-Binding Proteins
Enzyme Activation
MUTANT
GROWTH
HDA
bacteria
medicine.symptom
Energy Metabolism
Genome, Bacterial
Bacteria
INITIATION MASS
Subjects
Details
- ISSN :
- 14320983 and 01728083
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Current Genetics
- Accession number :
- edsair.doi.dedup.....64efe334e3a261981c63128b9245511e