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Quantifying exploratory low dose compounds in humans with AMS
- Source :
- Advanced Drug Delivery Reviews. 63:518-531
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Accelerator Mass Spectrometry is an established technology whose essentiality extends beyond simply a better detector for radiolabeled molecules. Attomole sensitivity reduces radioisotope exposures in clinical subjects to the point that no population need be excluded from clinical study. Insights in human physiochemistry are enabled by the quantitative recovery of simplified AMS processes that provide biological concentrations of all labeled metabolites and total compound related material at non-saturating levels. In this paper, we review some of the exploratory applications of AMS (14)C in toxicological, nutritional, and pharmacological research. This body of research addresses the human physiochemistry of important compounds in their own right, but also serves as examples of the analytical methods and clinical practices that are available for studying low dose physiochemistry of candidate therapeutic compounds, helping to broaden the knowledge base of AMS application in pharmaceutical research.
- Subjects :
- Clinical Trials as Topic
education.field_of_study
Dose-Response Relationship, Drug
Drug-Related Side Effects and Adverse Reactions
Microdosing
Chemistry
Pharmacological research
Population
Low dose
Pharmaceutical Science
Computational biology
Pharmacology
Mass Spectrometry
Article
Clinical study
Pharmaceutical Preparations
Pharmaceutical technology
Drug Design
Animals
Humans
Carbon Radioisotopes
Pharmaceutical sciences
education
Accelerator mass spectrometry
Subjects
Details
- ISSN :
- 0169409X
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- Advanced Drug Delivery Reviews
- Accession number :
- edsair.doi.dedup.....64ea27cd24979e9dcbf6c3cb960f586a