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Cost-Effectiveness of Antiepileptic Drugs in Migraine Prophylaxis
- Source :
- Headache: The Journal of Head and Face Pain. 42:978-983
- Publication Year :
- 2002
- Publisher :
- Wiley, 2002.
-
Abstract
- OBJECTIVE To analyze the cost-effectiveness of antiepileptics in migraine prophylaxis. METHODS A cost-effectiveness analysis was performed using efficacy data from three recent, double-blind, placebo-controlled, clinical trials of antiepileptic drugs studied for migraine prevention and cost data. Two measures of cost-effectiveness were used: cost per headache prevented and the cost-equivalent number. RESULTS In the double-blind, placebo-controlled, clinical trials evaluated, three antiepileptic drugs were shown to be effective in migraine prevention. All three antiepileptic drugs had high costs per migraine reduced. Gabapentin was the most costly at dollars 138.00 per migraine prevented, whereas the cost per migraine prevented with topiramate was US dollars 114.80 and with divalproex sodium was US dollars 48.00. For migraine prevention divalproex sodium became cost-effective with 10 migraines per month, whereas gabapentin and topiramate required considerably more migraines per month to be cost-effective. CONCLUSIONS Antiepileptic drugs have proven effectiveness in migraine prophylaxis. However, in patients responsive to their acute care medications, the antiepileptic drugs are only cost-effective for those patients with a high frequency of migraines and those with comorbid diseases. Future studies should be done with antiepileptic drugs in patients exhibiting a migraine frequency of 10 or more headaches per month.
- Subjects :
- Topiramate
Pediatrics
medicine.medical_specialty
Cyclohexanecarboxylic Acids
Gabapentin
Cost effectiveness
Cost-Benefit Analysis
Migraine Disorders
medicine.medical_treatment
Fructose
Acetates
Pharmacoeconomics
Medicine
Amines
gamma-Aminobutyric Acid
health care economics and organizations
Sumatriptan
business.industry
Valproic Acid
Models, Theoretical
medicine.disease
Serotonin Receptor Agonists
Clinical trial
Anticonvulsant
Neurology
Migraine
Anesthesia
Anticonvulsants
Neurology (clinical)
Headaches
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 15264610 and 00178748
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Headache: The Journal of Head and Face Pain
- Accession number :
- edsair.doi.dedup.....64e17e410442943a1a01623c0e1a8f68