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Lipid-weighted intraoperative photoacoustic tomography of breast tumors: Volumetric comparison to preoperative MRI
- Source :
- Photoacoustics, Vol 18, Iss, Pp 100165-(2020), Photoacoustics
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- With a lifetime risk of 1 in 8, breast cancer continues to be a major concern for women and their physicians. The optimal treatment of the disease depends on the stage of the cancer at diagnosis, which is typically assessed using medical imaging. However, currently employed imaging systems for breast tumor measurement rarely agree perfectly. Our group developed an Intraoperative Photoacoustic Screening (iPAS) soft tissue scanner featuring high bulk tissue sensitivity, a clinically compatible scan-time of 6 min, imaging depths greater than 2 cm and the capability to visualize whole breast tumors based on their lipid, rather than hemoglobin, profile. Here, we report on the first clinical experience with breast cancer patients by comparing tumor-measurement using iPAS, preoperative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and gold-standard pathology. Tumor size was measured volumetrically for iPAS and DCE-MRI, and separately using maximum diameters for pathology, DCE-MRI and iPAS. Comparisons were performed using Pearson’s correlation coefficients, and the non-parametric Wilcoxon signed-rank test. Twelve consecutive patients were included in the study, contingent on pathologically documented invasive carcinoma. iPAS volumetric tumor size was positively correlated to DCE-MRI (Pearson’s r = 0.78, p = 0.003) and not significantly different (Wilcoxon, p = 0.97). In comparison to pathology, tumor diameters given by iPAS were positively correlated (Pearson’s r = 0.87, p = 0.0002) and significantly different (Wilcoxon, p = 0.0015). The results indicated that volumetric-measurement of invasive breast tumors with iPAS is similar to that of DCE-MRI. On the other hand, tumor diameter measurements were less reliable. Beyond enhancing surgical specimen examination, an extension of this technology to diagnostic imaging promises a new perspective on tumor assessment, potentially improving our current understanding and treatment of breast cancer.
- Subjects :
- medicine.medical_specialty
Wilcoxon signed-rank test
lcsh:QC221-246
Dynamic contrast enhanced MRI
01 natural sciences
010309 optics
03 medical and health sciences
Acoustic transducers
Breast cancer
0302 clinical medicine
0103 physical sciences
medicine
Medical imaging
Tumor volume
lcsh:QC350-467
Radiology, Nuclear Medicine and imaging
Intraoperative imaging
Stage (cooking)
skin and connective tissue diseases
Photoacoustic tomography
medicine.diagnostic_test
business.industry
Soft tissue
Cancer
Magnetic resonance imaging
medicine.disease
lcsh:QC1-999
Atomic and Molecular Physics, and Optics
3. Good health
Lipid weighted imaging
030220 oncology & carcinogenesis
lcsh:Acoustics. Sound
Dynamic contrast-enhanced MRI
Radiology
business
lcsh:Physics
lcsh:Optics. Light
Research Article
Subjects
Details
- ISSN :
- 22135979
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Photoacoustics
- Accession number :
- edsair.doi.dedup.....64db085870cf90389733e751faa29047