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Semi-automated shear stress measurements in developing embryonic hearts
- Source :
- Biomed Opt Express
- Publication Year :
- 2020
- Publisher :
- Optica Publishing Group, 2020.
-
Abstract
- Blood-induced shear stress influences gene expression. Abnormal shear stress patterns on the endocardium of the early-stage heart tube can lead to congenital heart defects. To have a better understanding of these mechanisms, it is essential to include shear stress measurements in longitudinal cohort studies of cardiac development. Previously reported approaches are computationally expensive and nonpractical when assessing many animals. Here, we introduce a new approach to estimate shear stress that does not rely on recording 4D image sets and extensive post processing. Our method uses two adjacent optical coherence tomography frames (B-scans) where lumen geometry and flow direction are determined from the structural data and the velocity is measured from the Doppler OCT signal. We validated our shear stress estimate by flow phantom experiments and applied it to live quail embryo hearts where observed shear stress patterns were similar to previous studies.
- Subjects :
- Doppler OCT
0303 health sciences
medicine.diagnostic_test
Heart tube
01 natural sciences
Signal
Article
Atomic and Molecular Physics, and Optics
010309 optics
03 medical and health sciences
Optical coherence tomography
0103 physical sciences
Shear stress
medicine
Longitudinal cohort
Geology
Endocardium
030304 developmental biology
Biotechnology
Lumen (unit)
Biomedical engineering
Subjects
Details
- ISSN :
- 21567085
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Biomedical Optics Express
- Accession number :
- edsair.doi.dedup.....64d3acbc7509995269ad7b6578556c64
- Full Text :
- https://doi.org/10.1364/boe.395952