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COVID-19 in children. II: Pathogenesis, disease spectrum and management

COVID-19 in children. II: Pathogenesis, disease spectrum and management

Authors :
David Burgner
Emma Goeman
Philip N Britton
Archana Koirala
Daniel K Yeoh
Brendan McMullan
Annaleise R Howard-Jones
Paul Gray
Asha C. Bowen
Danielle Wurzel
Margie Danchin
Nigel W Crawford
Stephanie Kuek
Ketaki Sharma
Peter Hsu
Shidan Tosif
Source :
Journal of Paediatrics and Child Health
Publication Year :
2021

Abstract

The global disruption of the COVID-19 pandemic has impacted the life of every child either directly or indirectly. This review explores the pathophysiology, immune response, clinical presentation and treatment of COVID-19 in children, summarising the most up-to-date data including recent developments regarding variants of concern. The acute infection with SARS-CoV-2 is generally mild in children, whilst the post-infectious manifestations, including paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) and 'long COVID' in children, are more complex. Given that most research on COVID-19 has focused on adult cohorts and that clinical manifestations, treatment availability and impacts differ markedly in children, research that specifically examines COVID-19 in children needs to be prioritised.

Details

Language :
English
Database :
OpenAIRE
Journal :
Journal of Paediatrics and Child Health
Accession number :
edsair.doi.dedup.....64d1c0d3e993b639483d5fc9da494a99