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Short-term effects of comprehensive pulmonary rehabilitation and its maintenance in patients with idiopathic pulmonary fibrosis: A randomized controlled trial
- Source :
- J. Clin. Med. 9:1567 (2020), Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 9, Iss 1567, p 1567 (2020), Volume 9, Issue 5
- Publication Year :
- 2020
- Publisher :
- Mdpi, 2020.
-
Abstract
- The recommendation for pulmonary rehabilitation (PR) in idiopathic pulmonary fibrosis (IPF) is weak with low-quality evidence. Therefore, the aim of this study is to investigate short-term PR effects and their maintenance after a 3-month follow-up. Fifty-four IPF patients were randomized into a group receiving a 3-week comprehensive, inpatient PR (n = 34, FVC: 74 &plusmn<br />19% pred.) or usual care (UC) (n = 17, FVC: 72 &plusmn<br />20%pred.). Outcomes were measured at baseline (T1), after intervention (T2), and 3 months after T2 (T3). A 6-min walk distance (6MWD) was used as the primary outcome and chronic respiratory disease questionnaire (CRQ) scores as the secondary outcome. Change in 6MWD from T1 to T2 (&Delta<br />= 61 m, 95% CI (18.5&ndash<br />102.4), p = 0.006) but not from T1 to T3 (∆ = 26 m, 95% CI (8.0&ndash<br />61.5), p = 0.16) differed significantly between groups. Higher baseline FVC and higher anxiety symptoms were significant predictors of better short-term 6MWD improvements. For the change in CRQ total score, a significant between-group difference from T1 to T2 (∆ = 3.0 pts, 95% CI (0.7&ndash<br />5.3), p = 0.01) and from T1 to T3 (∆ = 3.5 pts, 95% CI (1.5&ndash<br />5.4), p = 0.001) was found in favour of the PR group. To conclude, in addition to the short-term benefits, inpatient PR is effective at inducing medium-term quality of life improvements in IPF. PR in the early stages of the disease seems to provoke the best benefits.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
lcsh:Medicine
Disease
Article
law.invention
03 medical and health sciences
Idiopathic pulmonary fibrosis
FEV1/FVC ratio
0302 clinical medicine
Quality of life
Randomized controlled trial
law
Internal medicine
medicine
In patient
Pulmonary rehabilitation
030212 general & internal medicine
exercise
business.industry
lcsh:R
Pulmonary Rehabilitation
Idiopathic Pulmonary Fibrosis
Exercise
Quality Of Life
General Medicine
respiratory system
medicine.disease
idiopathic pulmonary fibrosis
pulmonary rehabilitation
respiratory tract diseases
030228 respiratory system
quality of life
Anxiety
medicine.symptom
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- J. Clin. Med. 9:1567 (2020), Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 9, Iss 1567, p 1567 (2020), Volume 9, Issue 5
- Accession number :
- edsair.doi.dedup.....64c1e20029e4b92d450deae98fa4fc53