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Dentine as a bioactive extracellular matrix
- Source :
- Archives of Oral Biology. 57:109-121
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- As a mineralised connective tissue, dentine is well adapted to its functional role as a major structural component of the tooth. Although similar in composition to bone, dentine matrix is not remodelled physiologically and traditionally, has been regarded as a rather inert tissue. Nevertheless, dentine–pulp demonstrates strong regenerative potential which allows it to respond to disease and traumatic injury. Such responses are strongly influenced by cell–matrix interactions and modified by disease processes, including infection and inflammation. The identification of many bioactive molecules bound within dentine matrix has allowed their potential involvement in regenerative and other tissue responses to be better understood and new opportunities to be recognised for novel clinical therapies.
- Subjects :
- Functional role
Pathology
medicine.medical_specialty
Bioactive molecules
Connective tissue
Cell Communication
Matrix (biology)
Extracellular matrix
stomatognathic system
medicine
Humans
Regeneration
General Dentistry
Dental Pulp
Odontoblasts
Chemistry
Regeneration (biology)
Neuropeptides
Structural component
Cell Biology
General Medicine
Extracellular Matrix
Cell biology
stomatognathic diseases
medicine.anatomical_structure
Otorhinolaryngology
Dentin
Cytokines
Intercellular Signaling Peptides and Proteins
Subjects
Details
- ISSN :
- 00039969
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Archives of Oral Biology
- Accession number :
- edsair.doi.dedup.....64bfc0a464e222afcba033d1296a85ea