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Monoamine oxidase inhibitors isolated from fermented broths
- Source :
- The Journal of antibiotics. 26(3)
- Publication Year :
- 1973
-
Abstract
- Cultured broths were screened by measuring the inhibition of monoamine oxidase. Using serotonin as the substrate, two active agents were isolated from Actinomycetes and shown to be pimprinine and trans-cinnamic acid amide, and a compound isolated from a mushroom was identified to be harman. Using benzylamine as the substrate, an inhibitor was isolated from a Streptomyces and shown to be phenethylamine.
- Subjects :
- Phenethylamine
Serotonin
Indoles
Monoamine Oxidase Inhibitors
Chemical Phenomena
Monoamine oxidase
Pyridines
Streptomyces
chemistry.chemical_compound
Benzylamine
Alkaloids
Drug Discovery
Phenethylamines
Animals
Carbon Radioisotopes
Pharmacology
Mushroom
biology
Chemistry
Basidiomycota
Substrate (chemistry)
biology.organism_classification
Biochemistry
Liver
Cinnamates
Fermentation
Subjects
Details
- ISSN :
- 00218820
- Volume :
- 26
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Journal of antibiotics
- Accession number :
- edsair.doi.dedup.....64bce8ff7ce4ae6a270e73cbfbacd9fd