Serological immunoreactivity against colon cancer proteorne varies upon disease progression

Authors :: Angela Bachi
Stefano Olivieri
Massimo Alessio
Paolo Dellabona
Claudio Doglioni
Maria Pia Protti
Francesca Sanvito
Fiammetta Viganò
Matteo Frasson
Lucia De Monte
Marco Braga
De Monte, L
Sanvito, F
Olivieri, S
Vigano, F
Doglioni, C
Frasson, M
Braga, M
Bachi, A
Dellabona, P
Protti, M
Alessio, M
Doglioni, Claudio
Braga, Marco
Protti, Mp
Alessio, M.
Publication Year :: 2008
Publisher :: American Chemical Society, 2008.
Abstract: Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa.

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