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Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice
- Source :
- idUS. Depósito de Investigación de la Universidad de Sevilla, instname, Molecular psychiatry
- Publication Year :
- 2016
- Publisher :
- Nature Publishing Group, 2016.
-
Abstract
- NMDA glutamate receptors play key roles in brain development, function, and dysfunction. Regulatory roles of D-serine in NMDA receptor-mediated synaptic plasticity have been reported. Nonetheless, it is unclear whether and how neonatal deficits in NMDA-receptor-mediated neurotransmission affect adult brain functions and behavior. Likewise, the role of D-serine during development remains elusive. Here we report behavioral and electrophysiological deficits associated with the frontal cortex in Pick1 knockout mice, which show D-serine deficits in a neonatal and forebrain specific manner. The pathological manifestations observed in adult Pick1 mice are rescued by transient neonatal supplementation of D-serine, but not by a similar treatment in adulthood. These results indicate a role for D-serine in neurodevelopment and provide novel insights on how we interpret data of psychiatric genetics, indicating the involvement of genes associated with D-serine synthesis and degradation, as well as how we consider animal models with neonatal application of NMDA receptor antagonists.
- Subjects :
- 0301 basic medicine
Time Factors
Action Potentials
Cell Cycle Proteins
D-serine
Mice
0302 clinical medicine
Serine
Prefrontal cortex
Mice, Knockout
Neurons
prefrontal cortex
prepulse inhibition
Mental Disorders
Age Factors
Glutamate receptor
Nuclear Proteins
developmental trajectory
Frontal Lobe
PICK1
Psychiatry and Mental health
Schizophrenia
Dopamine Agonists
Knockout mouse
NMDA receptor
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Psychopharmacology
Psychology
Signal Transduction
Motor Activity
Neurotransmission
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
medicine
Animals
Maze Learning
Molecular Biology
Swimming
medicine.disease
Mice, Inbred C57BL
Disease Models, Animal
030104 developmental biology
NMDA
Synaptic plasticity
Exploratory Behavior
Carrier Proteins
Excitatory Amino Acid Antagonists
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- idUS. Depósito de Investigación de la Universidad de Sevilla, instname, Molecular psychiatry
- Accession number :
- edsair.doi.dedup.....64ae200016d1f7da99b4813e6a793a9f