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Pestalone, a New Antibiotic Produced by a Marine Fungus in Response to Bacterial Challenge
- Source :
- Journal of Natural Products. 64:1444-1446
- Publication Year :
- 2001
- Publisher :
- American Chemical Society (ACS), 2001.
-
Abstract
- The isolation and structure determination of a new chlorinated benzophenone antibiotic, pestalone (1), is described. The new compound was produced by a cultured marine fungus only when a unicellular marine bacterium, strain CNJ-328, was co-cultured in the fungal fermentation. The fungus, isolated from the surface of the brown alga Rosenvingea sp. collected in the Bahamas Islands, was identified as an undescribed member of the genus Pestalotia. The structure of 1, initially assigned with only modest confidence by combined spectral and chemical data, was confirmed by single-crystal X-ray analysis. Pestalone (1) exhibits moderate in vitro cytotoxicity in the National Cancer Institute's 60 human tumor cell line screen (mean GI(50) = 6.0 microM). More importantly, pestalone shows potent antibiotic activity against methicillin-resistant Staphylococcus aureus (MIC = 37 ng/mL) and vancomycin-resistant Enterococcus faecium (MIC = 78 ng/mL), indicating that pestalone should be evaluated in advanced models of infectious disease.
- Subjects :
- Staphylococcus aureus
Bahamas
medicine.drug_class
Enterococcus faecium
Antibiotics
Drug Evaluation, Preclinical
Pharmaceutical Science
Fungus
Crystallography, X-Ray
Phaeophyta
medicine.disease_cause
Analytical Chemistry
Microbiology
Benzophenones
Drug Discovery
Tumor Cells, Cultured
medicine
Pestalotiopsis
Nuclear Magnetic Resonance, Biomolecular
Chromatography, High Pressure Liquid
Antibacterial agent
Pharmacology
Antibiotics, Antineoplastic
Molecular Structure
biology
Organic Chemistry
Vancomycin Resistance
Fungi imperfecti
biology.organism_classification
Anti-Bacterial Agents
Complementary and alternative medicine
Molecular Medicine
Methicillin Resistance
Spectrophotometry, Ultraviolet
Mitosporic Fungi
Bacteria
Subjects
Details
- ISSN :
- 15206025 and 01633864
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Journal of Natural Products
- Accession number :
- edsair.doi.dedup.....64a42d43342cdcf582de5ca99b787432