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Compressive mechanical properties of rat and pig optic nerve head
- Source :
- J Biomech
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Glaucoma is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP), the primary risk factor for glaucoma, is thought to induce abnormally high strains in optic nerve head (ONH) tissues, which ultimately result in retinal ganglion cell damage and vision loss. The mechanisms by which excessive deformations result in vision loss remain incompletely understood. The ability of computational and in vitro models of the ONH to provide insight into these mechanisms, in many cases, depends on our ability to replicate the physiological environment, which in turn requires knowledge of tissue biomechanical properties. The majority of mechanical data published to date regarding the ONH has been obtained from tensile testing, yet compression has been shown to be the main mode of deformation in the ONH under elevated IOP. We have thus tested pig and rat ONH tissue using unconfined cyclic compression. The material constants C(1), obtained from fitting the stress vs. strain data with a neo-Hookean material model, were 428 [367, 488] Pa and 64 [53, 76] Pa (mean [95% Confidence Interval]) for pig and rat optic nerve head, respectively. Additionally, we investigated the effects of strain rate and tissue storage on C1 values. These data will inform future efforts to understand and replicate the in vivo biomechanical environment of the ONH.
- Subjects :
- Male
Retinal Ganglion Cells
medicine.medical_specialty
genetic structures
Swine
Rat Optic Nerve
Optic Disk
0206 medical engineering
Biomedical Engineering
Biophysics
Glaucoma
Strain (injury)
02 engineering and technology
Article
03 medical and health sciences
0302 clinical medicine
In vivo
Ophthalmology
Optic Nerve Diseases
medicine
Animals
Humans
Orthopedics and Sports Medicine
Intraocular Pressure
business.industry
Rehabilitation
Compression (physics)
medicine.disease
020601 biomedical engineering
eye diseases
Biomechanical Phenomena
Rats
medicine.anatomical_structure
Retinal ganglion cell
Optic nerve
Head (vessel)
Stress, Mechanical
sense organs
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00219290
- Volume :
- 93
- Database :
- OpenAIRE
- Journal :
- Journal of Biomechanics
- Accession number :
- edsair.doi.dedup.....6492dfb0fdfcbf0972703eacbb9ce2de