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Novel perylene probe-encapsulated metal-organic framework nanocomposites for ratiometric fluorescence detection of ATP

Authors :
Qiang Li
Juanmin Li
Li-Li Tan
Li Shang
Xiaomeng Zhou
Source :
Journal of materials chemistry. B. 8(16)
Publication Year :
2020

Abstract

Adenosine triphosphate (ATP) plays an important role in various biological processes and the ATP level is closely associated with many diseases. Herein, a novel ratiometric fluorescence assay for ATP was developed based on the excimer-monomer transfer of a perylene probe. By encapsulating a perylene probe, N,N'-bis(6-caproic acid)-3,4:9,10-perylenediimide (PDI), into zeolitic imidazolate framework-8 (ZIF-8) nanocrystals, fluorescent nanocomposites (PDI@ZIF-8) with significant excimer emission of the perylene probe were prepared for the first time. The presence of ATP will trigger the decomposition of PDI@ZIF-8 due to much stronger coordination between ATP and Zn2+ than that of 2-methylimidazole and Zn2+. As a result, the encapsulated PDI probes were released, leading to significantly increased monomer emission accompanying the decrease in the excimer emission. The excimer-monomer transition signal was utilized for ratiometric ATP sensing and its potential application for detecting ATP in cell lysates was also successfully demonstrated.

Details

ISSN :
20507518
Volume :
8
Issue :
16
Database :
OpenAIRE
Journal :
Journal of materials chemistry. B
Accession number :
edsair.doi.dedup.....6492a204a3958be454b98576a604f724