Back to Search
Start Over
Proportion of Cytotoxic Peripheral Blood Natural Killer Cells and T-Cell Large Granular Lymphocytes in Recurrent Miscarriage and Repeated Implantation Failure: Case-Control Study and Meta-analysis
- Source :
- Archivum immunologiae et therapiae experimentalis. 67(4)
- Publication Year :
- 2018
-
Abstract
- We aimed to compare the proportion of peripheral blood natural killer (NK) cells (CD3–CD56+) and T-cell large granular lymphocytes (CD8+CD57+) during preconception in a homogenous group of women with unexplained well-defined recurrent miscarriage (RM) and repeated implantation failure (RIF) vs healthy controls in relation to pregnancy outcomes. This case–control study followed by a literature review and meta-analysis was conducted in three university hospitals. Patients and controls were consecutively recruited from December 2015 to October 2017. In total, 115 women were included in the study: 54 with RM, 41 with RIF and 20 healthy controls with ≥ 2 term births. Percentages of CD3–CD56+ and CD8+CD57+ cells and sub-populations of CD3–CD56+ cells did not differ between cases and controls. The results for women with subsequent miscarriage did not differ from those with live births. The meta-analysis of the literature showed higher NK-cell proportions in RM [mean difference 3.47 (95% CI 2.94–4.00); p
- Subjects :
- Adult
Cytotoxicity, Immunologic
medicine.medical_specialty
Abortion, Habitual
Adolescent
T cell
Immunology
Cell Count
CD8-Positive T-Lymphocytes
Gastroenterology
Miscarriage
Natural killer cell
03 medical and health sciences
Young Adult
0302 clinical medicine
Immune system
CD57 Antigens
Pregnancy
Internal medicine
Recurrent miscarriage
medicine
Immunology and Allergy
Cytotoxic T cell
Humans
Embryo Implantation
Blood Cells
business.industry
Case-control study
Pregnancy Outcome
General Medicine
Middle Aged
medicine.disease
CD56 Antigen
Killer Cells, Natural
medicine.anatomical_structure
Case-Control Studies
Female
business
CD8
030215 immunology
Subjects
Details
- ISSN :
- 16614917
- Volume :
- 67
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Archivum immunologiae et therapiae experimentalis
- Accession number :
- edsair.doi.dedup.....64853286c9df133afa5bce1252db61ec