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Expression of TRPC3 in cortical lesions from patients with focal cortical dysplasia
- Source :
- Neuroscience letters. 724
- Publication Year :
- 2019
-
Abstract
- Focal cortical dysplasia (FCD) is one of the main causes of medically intractable epilepsy. Some studies have reported that transient receptor potential canonical channel 3 (TRPC3) may play an important role in the occurrence of seizures. In this study, we investigated the expression patterns of TRPC3 in different types of FCD. Forty-five FCD specimens and 12 control samples from autopsies were used in our study. Western blotting, immunohistochemistry, and immunofluorescence staining were employed to detect protein expression and distribution. The amount of TRPC3 protein was markedly elevated in the FCD group. The immunohistochemistry results revealed that TRPC3 staining was strong in the malformed cells and microcolumns. Most of the TRPC3-positive cells were colabeled with glutamatergic and GABAergic markers. The overexpression and altered cellular distribution of TRPC3 in the FCD samples suggest that TRPC3 may be related to epileptogenesis in FCD.
- Subjects :
- 0301 basic medicine
Male
Pathology
medicine.medical_specialty
Adolescent
Gene Expression
Biology
Epileptogenesis
03 medical and health sciences
Epilepsy
Glutamatergic
Young Adult
0302 clinical medicine
TRPC3
medicine
Humans
Child
TRPC Cation Channels
Cerebral Cortex
General Neuroscience
Cortical dysplasia
medicine.disease
Blot
Malformations of Cortical Development
030104 developmental biology
Child, Preschool
Immunohistochemistry
GABAergic
Female
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18727972
- Volume :
- 724
- Database :
- OpenAIRE
- Journal :
- Neuroscience letters
- Accession number :
- edsair.doi.dedup.....64823545a08c9e920adfe1b13eedfd38